Neurocysticercosis: treatment with albendazole and dextrochloropheniramine (preliminary report).
نویسندگان
چکیده
T h e c l i n i c a l v a r i a b i l i t y o f neu rocys t i ce rcos i s is d u e to a series of f ac to r s such as n u m b e r , l o c a t i o n , f o r m , d i m e n s i o n s a n d s tage of d e v e l o p m e n t of the p a r a s i t e , the n a t u r e of its a c t i on o n the o r g a n i s m a n d the ind iv idua l i m m u n o l o g i c a l r e s p o n s e of the hosu .4 ,6 . T h u s , d i a g n o s i s is very d i f f i c u l t , especial ly in no t highly e n d e m i c a r ea s or in r eg ions were l a b o r a t o r y s u p p o r t is l a c k i n g . A n o t h e r i m p o r t a n t f e a t u r e to be c o n s i d e r e d in the a p p r o a c h to neu rocys t i ce r cos i s is t he lack of a n a l t e r n a t i v e p r o g r a m o f a n t i p a r a s i t i c t r e a t m e n t . T h e h igh coas t of t r e a t m e n t wi th p r a z i q u a n t e l a n d t h e s i d e e f f e c t s ' o f c o r t i c o s t e r o i d s 5 a r e fac tors that h a v e led to the search for new t r e a t m e n t p r o g r a m s .
منابع مشابه
Severe forms of neurocysticercosis: treatment with albendazole.
Study of 22 patients with the severe form of neurocysticercosis treated with albendazole (ABZ) administered in 6 different schedules ranging from 15 to 30 mg/kg/day for 21 to 60 days. Dextrochloropheniramine and ketoprofen were the adjuvant drugs. Multiple symptoms were observed in 90.9% of patients. Intracranial hypertension was manifested in 90.9%. Hydrocephaly occurred in 86.4%. Evolution wa...
متن کاملFollow-up of neurocysticercosis patients after treatment using an antigen detection ELISA.
Seven patients with active neurocysticercosis (NCC) received an eight days treatment with albendazole and were followed up using computed tomography (CT-scan) and a monoclonal antibody based ELISA for the detection of circulating antigen (Ag-ELISA). Only three patients were cured as was shown by CT-scan and by the disappearance of circulating antigens one month after treatment. After a second c...
متن کاملShort course of albendazole therapy for neurocysticercosis: A prospective randomized trial comparing three days, eight days and the control group without albendazole
ABSTRACT: Antihelminthic therapy with albendazole for parenchymal cerebral cysticercosis, despite its widespread acceptance, is still the subject of controversy. In this prospective, randomized clinical trial, we compared the effectiveness of two regimens of albendazole therapy for neurocysticercosis against each other and against symptomatic therapy alone. A first group (27 patients) received ...
متن کاملCase Report A case of imported neurocysticercosis in Portugal
Neurocysticercosis (NCC) is the most common cause of acquired epilepsy in resource-poor countries. We report the case of a 24-year-old woman born and residing in Guinea-Bissau, who was transferred to Portugal two months after the onset of a possible meningitis (fever, headache, seizures, and coma) that did not respond to antibiotic treatment. The diagnosis of NCC was confirmed by MR imaging, wh...
متن کاملAlbendazole versus Praziquantel in the Treatment of Neurocysticercosis: A Meta-analysis of Comparative Trials
BACKGROUND Neurocysticercosis, infection of the brain with larvae of Taenia solium (pork tapeworm), is one of several forms of human cysticercosis caused by this organism. We investigated the role of albendazole and praziquantel in the treatment of patients with parenchymal neurocysticercosis by performing a meta-analysis of comparative trials of their effectiveness and safety. METHODS AND PR...
متن کاملAlbendazole treatment of neurocysticercosis.
Neurocysticercosis (NC) is a common parasito sis affecting the central nervous system. It is en demic in many developing countries. PraziquanteI was the first drug to show potential efficacy for treatment of NC (Sotelo et ai, 1984). Recently albendazole, an imidazole with activity against in testinal and systemic infections by trematodes and cestodes (Anonymous, 1984), demonstrated its effic...
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ورودعنوان ژورنال:
- Revista do Instituto de Medicina Tropical de Sao Paulo
دوره 30 5 شماره
صفحات -
تاریخ انتشار 1988